Abstract

Research Article

Preparation, solid state characterization and evaluation of ketoprofen-glucosamine HCl solid dispersions

Abdul Wahab, Gul Majid Khan*, Mohsen Sharifi, Ahmad Khan, Amjad Khan and Naqab Khan

Published: 26 June, 2018 | Volume 2 - Issue 1 | Pages: 010-019

In this investigation, solid dispersions were prepared and characterized to improve the solubility and dissolution of poorly water soluble drug Ketoprofen, using glucosamine HCl as a carrier. For the improvement of the solubility and dissolution rate of poorly water soluble drugs different techniques are used such as solubilization, salt formation, particle size reduction and solid dispersion etc, but in the present study, solid dispersions (SDs) of poorly water soluble NSAID Ketoprofen were prepared to improve its solubility and dissolution rate, using solvent evaporation method with drug-carrier ratio of 1:1, 1:2 and 1:3. Our results indicate that all solid dispersions of Ketoprofen and Glucosamine HCl exhibited more enhancements in solubility and dissolution rates than corresponding physical mixtures. The DSC thermograms and X-ray diffraction patterns showed a slight reduction in crystallinity in solid dispersions which were further verified by FT-IR and SEM. It is concluded that solid dispersion is an effective technique for enhancing the solubility and dissolution rate of poorly water-soluble drug Ketoprofen using Glucosamine HCl as a carrier. This amino sugar (Glucosamine HCl) could be used as a novel potential carrier for preparation and formulation of SDs and would have potential commercial benefits.

Read Full Article HTML DOI: 10.29328/journal.apps.1001007 Cite this Article Read Full Article PDF

Keywords:

Ketoprofen; Glucosamine HCl; Solid dispersions; Physical Mixtures; Solubility; Drug release rate

References

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