Abstract

Research Article

Preclinical studies for a cationic liposome formulation containing Il-2 Intended for the treatment of Human Tumors

Maria Teresa Corona-Ortega*, Arturo Valle-Mendiola, Leonor Aguilar-Santelises, Araceli Garcia del Valle, Rosalva Rangel-Corona and Benny Weiss-Steider

Published: 29 October, 2018 | Volume 2 - Issue 1 | Pages: 051-059

Human cervical cancer tumours expressing the IL-2 receptor (IL-2R) were induced in the peritoneal cavity of nude mice. The tumours were significantly reduced by the i.p. administration of either free IL-2 or liposomes containing this growth factor. No toxicity was observed in the mice even at the highest doses of IL-2 in liposomes. We did not detect any IL-2 in the blood plasma pointing to a strong retention of the liposomes on the cavity. We concluded that this preclinical study for the treatment of tumours expressing IL-2R in the peritoneal cavity is effective and safe. The liposomes were stable and their IL-2 active for up to one year when kept at -14oC in a cryopreservation media approved by the FDA for human use.

Read Full Article HTML DOI: 10.29328/journal.apps.1001010 Cite this Article Read Full Article PDF

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