Research Article

Medicinal plant extract associated with bacterial cellulose membrane: Antibacterial activity and physicochemical properties

Fernando Batain, Kessi Crescencio, Thais Alves, Juliana Ferreira Souza, Venâncio Amaral, Juliana Castro, Carolina Santos, Angela Jozala, Luciane Lopes* and Marco Chaud*

Published: 04 February, 2020 | Volume 4 - Issue 1 | Pages: 013-020

Burns injuries induce a state of immunodepression that predisposes to a bacterial infectious complication that leads to several comorbid diseases and high mortality rate. Previous studies about anti-inflammatory, antimicrobial and antioxidant properties of Aloe vera (L.) Burm., Calendula officinalis L.and Matricaria recutita L. are acknowledge by antimicrobial effects.

Previous studies about anti-inflammatory, antimicrobial and antioxidant properties of Aloe vera (L.) Burm., Calendula officinalis L. and Matricaria recutita L. are knowledge by antimicrobial effects. Bacterial cellulose membrane (nature BCM) is a potential carrier as a drug delivery system in the wound and burn treatment. The present study aimed to evaluate the antibacterial activity of extracts of A. vera, C. officinalis, and M. recutita incorporated in BCM against bacterial strains commonly present in wound and burns. The agar-dilution susceptibility testing was used to determine the minimum inhibitory concentration (MIC) for S. aureus, E. coli, and P. aeruginosa. The standardized extracts of A. vera, M. recutita, and C. officinalis were, respectively, used at 3.25% of total polysaccharides, 1% of apigenin 7-O-glucoside and 0.084% of total flavonoids expressed in quercetin. The BCM incorporated with A. vera extract was efficient to prevent the growth of P. aeruginosa and S. aureus. BCM loaded with C. officinalis inhibited the growth of S. aureus. The BCM loaded with A. vera and C. officinalis extract showed better antibacterial activities against P. aeruginosa and S. aureus and, consequently, properties to prevent infectious disease in the wound or burn caused by these bacteria.

Read Full Article HTML DOI: 10.29328/journal.apps.1001022 Cite this Article Read Full Article PDF


Bacterial cellulose membranes; Aloe vera. Matricaria recutita. Calendula officinalis; Burn; Wound healing


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