Abstract

Review Article

Cytotoxic Effects of Aminotriles with Bioactive Potential: An Integrative Review

Paola da Costa Vieira, Lettícia Tenório Cavalcanti, Hélida Maravilha Dantas e Sousa Almeida and Igor de Sousa Oliveira and Sávio Benvindo Ferreira*

Published: 09 May, 2023 | Volume 7 - Issue 1 | Pages: 022-027

Aminonitriles are pharmacological-interest bioactive due to their promising antimicrobial and antitumor activity. Since cytotoxicity tests are inherent to the new drug development process, this work aimed to verify reports in the scientific literature on the cytotoxic effects of aminonitriles. The method adopted was an integrative review of works published in the last 10 years in the PubMed, Embase, Web of Science, and Virtual Health Library (VHL) databases. Three articles that matched the selection and eligibility criteria were included in this review. A total of 33 aminonitriles were used in the cytotoxicity experiments, and of the nine molecules based on pyridine, two exerted moderate cytotoxic activity, of the twelve synthesized from benzimidazole, none showed cytotoxic activity, and of the twelve derived from renieramycins, all showed considerable cytotoxic activities. The studies used in this research evaluated the cytotoxic effects of aminonitriles with evident anticancer and antimicrobial activity. The importance of evaluating the cytotoxicity of aminonitriles is emphasized, as well as the need for investigative research that explores other evaluation methods in pre-clinical tests that may corroborate the existing findings, with a view to the development of therapies against emerging health problems.

Read Full Article HTML DOI: 10.29328/journal.apps.1001040 Cite this Article Read Full Article PDF

Keywords:

Aminonitriles; Cytotoxicity; Cellular effects; Drug development

References

  1. Kouznetsov VV, Galvis CEP. Strecker reaction and α-amino nitriles: Recent advances in their chemistry, synthesis, and biological properties. Tetrahedron. 2018 Feb 22; 74(8):773–810.
  2. Grundke C, Vierengel N, Opatz T. α -Aminonitriles: From Sustainable Preparation to Applications in Natural Product Synthesis. Chem Rec. 2020 Sep;20(9):989-1016. doi: 10.1002/tcr.202000066. Epub 2020 Jul 24. PMID: 32706179.
  3. Shalayel I, Coulibaly S, Ly KD, Milet A, Vallée Y. The Reaction of Aminonitriles with Aminothiols: A Way to Thiol-Containing Peptides and Nitrogen Heterocycles in the Primitive Earth Ocean. Life (Basel). 2018 Oct 19;8(4):47. doi: 10.3390/life8040047. PMID: 30347745; PMCID: PMC6316830.
  4. Almeida HM, Oliveira I, Ferreira S. Aminonitrile Potential in Terms of Pharmacological and Clinical Applicability. 2021 Feb 21. https://sciforum.net/paper/view/9258
  5. Masson AO, Nascimento MHM, Lombello CB. Análise comparativa de diferentes métodos de citotoxicidade in vitro. In: XXIV Congresso Brasileiro de Engenharia Biomédica – CBEB. Uberlândia; 2014; 2484-2488.
  6. Andrade EL, Bento AF, Cavalli J, Oliveira SK, Schwanke RC, Siqueira JM, Freitas CS, Marcon R, Calixto JB. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies. Braz J Med Biol Res. 2016 Dec 12;49(12):e5646. doi: 10.1590/1414-431X20165646. PMID: 27982281; PMCID: PMC5188860.
  7. Dhollande S, Taylor A, Meyer S, Scott M. Conducting integrative reviews: a guide for novice nursing researchers. J Res Nurs. 2021 Aug;26(5):427-438. doi: 10.1177/1744987121997907. Epub 2021 Aug 5. PMID: 35251272; PMCID: PMC8894639.
  8. Stern C, Jordan Z, McArthur A. Developing the review question and inclusion criteria. Am J Nurs. 2014 Apr;114(4):53-6. doi: 10.1097/01.NAJ.0000445689.67800.86. PMID: 24681476.
  9. Agency for Heathcare Research and Quality. AHRQ Indicators. Agency for Heathcare Research and Quality. [cited 2022 Sep 13]. https://qualityindicators.ahrq.gov/
  10. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71. PMID: 33782057; PMCID: PMC8005924.
  11. Graphpad Software. Prism. Prism. https://www.graphpad.com/scientific-software/prism/
  12. Nakai K, Kubo K, Yokoya M, Saito N. Preparation of renieramycin left-half model compounds. Tetrahedron. 2014 Sep 16; 70(37):6529–45.
  13. Madácsi R, Traj P, Hackler Jr L, Nagy LI, Kari B, Puskás LG, Kanizsai I. Synthesis and biological evaluation of 4,5,6,7-tetrahydrothieno[2,3-c]pyridine–based β-aminonitriles and their derivatives: β-amino carboxamides, (thio)ureas, and tetracycles. Journal of Heterocyclic Chemistry. 2020; 57(2):635–52.
  14. Shaikh IN, Hosamani KM, Kurjogi MM. Design, synthesis, and evaluation of new α-aminonitrile-based benzimidazole biomolecules as potent antimicrobial and antitubercular agents. Arch Pharm (Weinheim). 2018 Feb;351(2). doi: 10.1002/ardp.201700205. Epub 2018 Jan 22. PMID: 29356105.
  15. Lupatini E de O, Barreto JOM, Zimmermann IR, Silva EN da. Medicamentos e pesquisa translacional: etapas, atores e políticas de saúde no contexto brasileiro. Saúde debate. 2020 Feb 10;43:181–99.
  16. Masson AO, Lombello CB. Cytotoxic evaluation methodologies: comparative study according to exposure time. In Foz do Iguaçu; 2016; 1–12. http://slabo.org.br/cont_anais/anais_9_colaob/manuscript/13-032TT.pdf
  17. Dobrovolskaia MA, McNeil SE. Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines. J Control Release. 2013 Dec 10;172(2):456-66. doi: 10.1016/j.jconrel.2013.05.025. Epub 2013 Jun 3. PMID: 23742883; PMCID: PMC5831149.
  18. Garattini S, Grignaschi G. Animal testing is still the best way to find new treatments for patients. Eur J Intern Med. 2017 Apr;39:32-35. doi: 10.1016/j.ejim.2016.11.013. Epub 2016 Dec 1. PMID: 27916437.
  19. Assay Guidance Manual. https://ncats.nih.gov/expertise/preclinical/agm
  20. de Araújo JSC, de Castilho ARF, Lira AB, Pereira AV, de Azevêdo TKB, de Brito Costa EMM, Pereira MDSV, Pessôa HLF, Pereira JV. Antibacterial activity against cariogenic bacteria and cytotoxic and genotoxic potential of Anacardium occidentale L. and Anadenanthera macrocarpa (Benth.) Brenan extracts. Arch Oral Biol. 2018 Jan;85:113-119. doi: 10.1016/j.archoralbio.2017.10.008. Epub 2017 Oct 14. PMID: 29054025.
  21. Valáriková J, Čížová A, Račková L, Bystrický S. Anti-staphylococcal activity of quaternized mannan from the yeast Candida albicans. Carbohydr Polym. 2020 Jul 15;240:116288. doi: 10.1016/j.carbpol.2020.116288. Epub 2020 Apr 18. PMID: 32475569.

Similar Articles

Recently Viewed

  • Antibacterial Screening of Lippia origanoides Essential Oil on Gram-negative Bacteria
    Rodrigo Marcelino Zacarias de Andrade, Bernardina de Paixão Santos, Roberson Matteus Fernandes Silva, Mateus Gonçalves Silva*, Igor de Sousa Oliveira, Sávio Benvindo Ferreira and Rafaelle Cavalcante Lira Rodrigo Marcelino Zacarias de Andrade, Bernardina de Paixão Santos, Roberson Matteus Fernandes Silva, Mateus Gonçalves Silva*, Igor de Sousa Oliveira, Sávio Benvindo Ferreira, Rafaelle Cavalcante Lira. Antibacterial Screening of Lippia origanoides Essential Oil on Gram-negative Bacteria. Arch Pharm Pharma Sci. 2024: doi: 10.29328/journal.apps.1001053; 8: 024-028.
  • Orofacial manifestations of COVID-19
    Hariharan Ramakrishnan* and Maniamuthu Ragupathi Hariharan Ramakrishnan*,Maniamuthu Ragupathi. Orofacial manifestations of COVID-19 . J Oral Health Craniofac Sci. 2021: doi: 10.29328/journal.johcs.1001034; 6: 006-007
  • Approaching Mental Health Through a Preventive Data Analysis Platform
    Gabriel F Pestana and Olga Valentim* Gabriel F Pestana, Olga Valentim*. Approaching Mental Health Through a Preventive Data Analysis Platform. Arch Psychiatr Ment Health. 2024: doi: 10.29328/journal.apmh.1001052; 8: 020-027
  • Second Stage of Labor Cesarean Section Maternal and Fetal Outcomes
    Ahazeej Gurashi, Ameer Osman, Hajar Suliman, Ayat Eltigani, Isra Siralkatim, Hamza Orfali and Awadalla Abdelwahid Suliman* Ahazeej Gurashi, Ameer Osman, Hajar Suliman, Ayat Eltigani, Isra Siralkatim, Hamza Orfali, Awadalla Abdelwahid Suliman*. Second Stage of Labor Cesarean Section Maternal and Fetal Outcomes. Clin J Obstet Gynecol. 2024: doi: 10.29328/journal.cjog.1001159; 7: 025-033
  • Surgical and Delivery Outcomes of Coexisting Uterine Fibroids with Pregnancies in Nigeria
    Ade-Ojo Idowu Pius* and Odetola Amoo A Ade-Ojo Idowu Pius*, Odetola Amoo A. Surgical and Delivery Outcomes of Coexisting Uterine Fibroids with Pregnancies in Nigeria. Clin J Obstet Gynecol. 2024: doi: 10.29328/journal.cjog.1001161; 7: 037-041

Read More

Most Viewed

Read More

Help ?