Modulation of Microbiota and its Impact on Depression

Main Article Content

Kousik Maparu

Abstract

Gut microbial flora is the largest micro-ecosystem in the human body, it is symbiotically associated with the host; and maintains normal physiological processes in a dynamic equilibrium state. A plethora of evidence supports that gut microbial flora influences the neurotransmitters of the central nervous system. This gut flora influences cognitive function, anxiety, depression; and mood disorders as they are capable of synthesizing neurotransmitters in the nervous system. Therefore intake of probiotics influences gut microbiome; and depression. The versatility and number of gut microbial flora varies individually, so the content of common gut microbes may affect the neurotransmitters, manipulating the gut microbiota with probiotics offers a novel approach to treat brain disorders such as depression via GUT-BRAIN AXIS. The present review outlines the aspect of such alterations and how modulation of gut microbiota influences depression.

Article Details

Maparu, K. (2024). Modulation of Microbiota and its Impact on Depression. Archives of Pharmacy and Pharmaceutical Sciences, 8(1), 089–090. https://doi.org/10.29328/journal.apps.1001061
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Copyright (c) 2024 Maparu K.

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