Preparation, solid state characterization and evaluation of ketoprofen-glucosamine HCl solid dispersions
Article Sidebar
Main Article Content
Abstract
In this investigation, solid dispersions were prepared and characterized to improve the solubility and dissolution of poorly water soluble drug Ketoprofen, using glucosamine HCl as a carrier. For the improvement of the solubility and dissolution rate of poorly water soluble drugs different techniques are used such as solubilization, salt formation, particle size reduction and solid dispersion etc, but in the present study, solid dispersions (SDs) of poorly water soluble NSAID Ketoprofen were prepared to improve its solubility and dissolution rate, using solvent evaporation method with drug-carrier ratio of 1:1, 1:2 and 1:3. Our results indicate that all solid dispersions of Ketoprofen and Glucosamine HCl exhibited more enhancements in solubility and dissolution rates than corresponding physical mixtures. The DSC thermograms and X-ray diffraction patterns showed a slight reduction in crystallinity in solid dispersions which were further verified by FT-IR and SEM. It is concluded that solid dispersion is an effective technique for enhancing the solubility and dissolution rate of poorly water-soluble drug Ketoprofen using Glucosamine HCl as a carrier. This amino sugar (Glucosamine HCl) could be used as a novel potential carrier for preparation and formulation of SDs and would have potential commercial benefits.
Article Details
Copyright (c) 2018 Wahab A, et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Elkordy AA, Ebtessam AE. Dissolution of Ibuprofen from Spray Dried and Spray Chilled Particles. Pak J Pharm Sci. 2010; 23: 284-290. Ref.: https://tinyurl.com/yc9yr2jd
Chaulang G, Piyush P, Sharwaree H, Mukul K, Ashok B, et al. Formulation and Evaluation of Solid Dispersions of Furosemide in Sodium Starch Glycolate. Trop J Pharm Res. 2009; 8: 43-51. Ref.: https://tinyurl.com/ybs9bgdr
Naseem A, Olliff CJ, Martini LG, Lioyd AW. Effects of plasma irradiation on the wettability and dissolution of compacts of griseofulvin. Int J Pharm. 2004; 269: 443-450. Ref.: https://tinyurl.com/y8mvlkuf
Galia E, Nicolaides E, Horters D, Lobenberg R, Reppasc, et al. Evaluation of various dissolution media for predicting invivo performance of class I & II drugs. Pharm Res. 1998; 15: 698-705. Ref.: https://tinyurl.com/ya2ftbhv
Noyes AA, Whitney WR. The rate of solution of solid substances in their own solutions. J Am Chem Soc. 1897; 19: 930-934. Ref.: https://tinyurl.com/y9g5rfnk
Khan GM, Zhu JB. Preparation, characterization, and dissolution studies of ibuprofen solid dispersions using polyethyleneglycol (PEG), talc, and PEG-talc as dispersion carriers. Drug Dev Ind Pharm. 1998; 24: 455-462. Ref.: https://tinyurl.com/yd8hbce8
Damian F, Blaton N, Naesens L. Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with Polyethylene glycol 6000 and Gelucire 44/14. Eur J Pharm Sci. 2000; 10: 311-322. Ref.: https://tinyurl.com/ya4gex7w
Craig DQ. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm. 2002; 231: 131-144. Ref.: https://tinyurl.com/ycw3phus
Khan GM, Zhu JB. Dissolution studies of ibuprofen powders: Effect of particle size on dissolution rate and simulation of dissolution process of mixed binary systems. J Chinese Pharm Sci. 1998; 7: 11-17.
Al-Hamidi H, Edwards AA, Mohammad AA, Nokhodchi A. To enhance dissolution rate of poorly water-soluble drugs: Glucosamine hydrochloride as a potential carrier in solid dispersion formulations. Colloids Surf B Biointerfaces. 2010; 76: 170-178. Ref.: https://tinyurl.com/y8oevafd
Wahab A, Khan GM, Akhlaq M, Khan NR, Hussain A, et al. Formulation and Evaluation of Controlled Release matrices of Ketoprofen and influence of different Co-excipients on the Release Mechanism. Pharmazie. 2011; 66: 677-683. Ref.: https://tinyurl.com/y9tz8mdg
Hussain A, Khan GM, Shah SU, Shah KU, Rahim N, et al. Development of a novel ketoprofen transdermal patch: effect of almond oil as penetration enhancer on in-vitro and ex-vivo penetration of ketoprofen through rabbit skin. Pak J Pharm Sci. 2012; 25: 227-232. Ref.: https://tinyurl.com/y85zp5qs
Parsad KA, Narayanan N, Rajalakshmi G. Preparation and Evaluation of Solid Dispersion of Terbinafine Hydrochloride. Int J Pharm Sci Rev Res. 2010; 3: 130-134. Ref.: https://tinyurl.com/yap9noea
Jain R, Jain Kaushal, Setty CM, Patel D. Preparation and Evaluation of Solid Dispersions of Aceclofenac. Int J Pharm Sci Drug Res. 2009; 1: 32-35.
Rosario P, Maranilla F, Giovanni P. Preparation of solid dispersions of nonsteroidal anti-inflammatory drugs with acrylic polymers and studies on mechanisms of drug-polymer interactions. AAPS PharmSciTec. 2002; 3: 10. Ref.: https://tinyurl.com/ydbqr5o9
Khan GM, Jiabi Z. Formulation and In-vitro Evaluation of Ibuprofen-carbopol 974-NP Controlled-release Matrix Tablets. III: Influence of Co-excipients on the Release Rate of the Drug. J Control Release. 1998; 54: 185-190. Ref.: https://tinyurl.com/ycn69cqr
Nagarsenkar MS, Hira S. Influence of Hydroxypropyl β-Cyclodextrin on Solubility and Dissolution Profile of Ketoprofen in Its Solid Dispersions. Drug Development and Industrial Pharmacy. 1996; 22: 9-10. Ref.: https://tinyurl.com/ya963cxb
Sancin P, Caputo O, Cavallari C, Passerini N, Rodriguez L. Effects of ultrasound-assisted Compaction on Ketoprofen/ Eudragit S100 Mixtures. Eur J Pharm Sci. 1999; 7: 207-213. Ref.: https://tinyurl.com/yb9nlrvp
Mura P, Bettinetti GP, Manderjoli A, Favcci MT, Bramanti G, et al. Interactions of ketoprofen and Ibuprofen with β-cyclodextrins, in Solution and in the Solid State. Int J Pharm. 1998; 166: 189-203. Ref.: https://tinyurl.com/ya3rnagq
Shivakumar HN, Sarasija S, Desai BG. Design and Evaluation of Cotrolled onset extended release multiparticulate systems for chronotherapeutic delivery of ketoprofen. Indian J Pharm Sci. 2008; 66: 76-82. Ref.: https://tinyurl.com/y9fxeyko
Ford JL. The current status of solid dispersions. Pharm Acta Helv. 1986; 61: 69-88. Ref.: https://tinyurl.com/ybvjg5t4
Martinez-Oharriz MC, Rodrig-Espinosa C, Martin C, Goni MM, Trosllarduya MC, et al. Solid dispersions of diflunisal-PVP: Polymorphic and amorphous states of the drug. Drug Dev Ind Pharm. 2002; 28: 717-725. Ref.: https://tinyurl.com/y7c9ukkh