Application of the Pyphagor’s Theorem for Correction of Ki and Ka constants of enzyme inhibition and activation

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Submitted: September 19, 2018
Published: Oct 13, 2018
DOI: 10.29328/journal.apps.1001011
Keywords:
Quadratic forms of equations for correction of Ki and Ka constants

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VI Krupyanko
GK Skryabin Institute of Biochemistry and Physiology of Microorganism, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Prospect Nauki 5, Russia
PV Krupyanko
Center for Information Technologies on Transport LLC, 142060, Moskow, Domodedovo, MK-Region Barybino, str. Yuzhnaya 17, Russia

Abstract

The analysis of dependence of the length projection of Li vectors of biparametrical inhibited and activated (La) enzymatic reactions from the length projection of vectors of monoparametrical inhibited and activated enzymatic reactions on the basic σ0 plane in three-dimensional coordinate system, allows to deduct the quadratic forms of equations for the correction of the constants of inhibition (ki) and activation (Ka) of enzymes. Examples of correction of constants are given.

Article Details

Krupyanko, V., & Krupyanko, P. (2018). Application of the Pyphagor’s Theorem for Correction of Ki and Ka constants of enzyme inhibition and activation. Archives of Pharmacy and Pharmaceutical Sciences, 2(1), 060–068. https://doi.org/10.29328/journal.apps.1001011
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